Rats have always played a significant role as an animal model in obesity and diabetes studies. Recently, a Roux-en-Y gastric bypass rat surgery model has been developed as an obesity treatment model. However, studies have demonstrated that the Roux-en-Y gastric bypass surgical procedure not only leads to significant weight loss but it also leads to complete remission of Type 2 Diabetes Mellitus in 84% of patients. More interestingly, studies have demonstrated that the Type 2 Diabetes resolution occurs before the weight loss, suggesting that insulin sensitivity improves by a process that is independent of weight-loss. However the mechanism behind this remission is not well understood and the rat Roux-en-Y gastric bypass surgery model is being utilized to help understand this mechanism.
The Roux-en-Y gastric bypass surgery is a complicated surgery, and various techniques have been described. The Veterinary Bioscience Institute has undertaken the task of reviewing available literature and refining this surgical technique as well as improving pre-, peri- and post-operative care. This information is now being presented as part of the Advanced Principles of Gastrointestinal Surgery workshop taught by the Veterinary Bioscience Institute. This workshop emphasizes hands-on learning of gastroduodenal and gastrojejunal anastomosis, and gastric bypass. Gastrointestinal anatomy, gastrointestinal tissue handling, appropriate surgical instrumentation, suturing techniques and pre- and post-surgical animal care are reviewed. Attendees perform gastric bypass and duodenal switch in the adult laboratory rat.
Accreditation & Affiliations
The Veterinary Bioscience Institute (VBI) is an approved continuing education provider by
VBI’s training meets the following standards:
VBI’s courses and workshops also meet the requirements for Continuing Education Units of